People with HIV who take antiretroviral drugs before their health declines have a 96 percent lower risk of transmitting the virus to a partner, according to a breakthrough global study.

The large study that covered mainly heterosexual couples in Africa, India and the Americas was hailed by AIDS experts as a “game-changer” that will transform how the disease is managed, 30 years after it first surfaced.

Until now, antiretroviral therapy was known to improve the health of people infected with human immunodeficiency virus, but this is the first study to show a solid impact on preventing transmission to an HIV-negative partner.

“This is excellent news,” said Myron Cohen, lead investigator on the study and director of the Institute of Global Health and Infectious Diseases at the University of North Carolina at Chapel Hill. “This is the first randomized clinical trial to definitively indicate that an HIV-infected individual can reduce sexual transmission of HIV to an uninfected partner by beginning antiretroviral therapy sooner.”

The trial began in 2005 and included 1,763 couples — 97 percent of whom were heterosexual — and was carried out at 13 sites in countries including Brazil, Thailand, Zimbabwe, India and South Africa.

The HIV-infected partners included 890 men and 873 women.

The randomization phase was halted early once researchers realized that the drug regimen was having such a significant blocking effect on the risk of spreading the infection, which afflicts 33 million people worldwide.

Some couples were placed into a delayed group, in which the infected partner began taking antiretroviral therapy (ART) only when a type of T-cell known as CD4 dipped below 250 cells per millimeter cubed, or if he or she developed an AIDS-related illness.

The other group began taking ART immediately. In that group, just one case of HIV transmission was observed.

There were 27 HIV transmissions in the delayed group that could be traced directly to the infected partner, a difference the study described as “highly statistically significant.”

National Institute of Allergy and Infectious Diseases chief Anthony Fauci hailed the findings.

“Previous data about the potential value of antiretrovirals in making HIV-infected individuals less infectious to their sexual partners came largely from observational and epidemiological studies,” said Fauci.

“This new finding convincingly demonstrates that treating the infected individual — and doing so sooner rather than later — can have a major impact on reducing HIV transmission.”

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